01344nas a2200145   4500008004300000245009700043210006900140260001900209520085100228100002001079700002101099700002001120700002201140856003601162       2009                        en_Ud  00amRNA stability and the unfolding of gene expression in the long-period yeast metabolic cycle0 amRNA stability and the unfolding of gene expression in the longp  bBioMed Central3 aBackground: In yeast, genome-wide periodic patterns associated with energy-metabolic oscillations have been shown recently for both short (approx. 40 min) and long (approx. 300 min) periods.\\nResults: The dynamical regulation due to mRNA stability is found to be an important aspect of the genome-wide coordination of the long-period yeast metabolic cycle. It is shown that for periodic genes, arranged in classes according either to expression profile or to function, the pulses of mRNA abundance have phase and width which are directly proportional to the corresponding turnover rates.\\nConclusion: The cascade of events occurring during the yeast metabolic cycle (and their correlation with mRNA turnover) reflects to a large extent the gene expression program observable in other dynamical contexts such as the response to stresses/stimuli.1 aSoranzo, Nicola1 aZampieri, Mattia1 aFarina, Lorenzo1 aAltafini, Claudio  uhttp://hdl.handle.net/1963/3630