01400nas a2200169   4500008004100000245009000041210006900131260005000200520083200250100001401082700001801096700001501114700002201129700002201151700002101173856003601194       2011                        en  d00aAdaptation as a genome-wide autoregulatory principle in the stress response of yeast.0 aAdaptation as a genomewide autoregulatory principle in the stres  bThe Institution of Engineering and Technology3 aThe gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products.1 aEduati, F1 aDi Camillo, B1 aToffolo, G1 aAltafini, Claudio1 aDe Palo, Giovanna1 aZampieri, Mattia  uhttp://hdl.handle.net/1963/5106