%0 Journal Article %J BMC Systems Biology (2009) 3:18 %D 2009 %T mRNA stability and the unfolding of gene expression in the long-period yeast metabolic cycle %A Nicola Soranzo %A Mattia Zampieri %A Lorenzo Farina %A Claudio Altafini %X Background: In yeast, genome-wide periodic patterns associated with energy-metabolic oscillations have been shown recently for both short (approx. 40 min) and long (approx. 300 min) periods.\\nResults: The dynamical regulation due to mRNA stability is found to be an important aspect of the genome-wide coordination of the long-period yeast metabolic cycle. It is shown that for periodic genes, arranged in classes according either to expression profile or to function, the pulses of mRNA abundance have phase and width which are directly proportional to the corresponding turnover rates.\\nConclusion: The cascade of events occurring during the yeast metabolic cycle (and their correlation with mRNA turnover) reflects to a large extent the gene expression program observable in other dynamical contexts such as the response to stresses/stimuli. %B BMC Systems Biology (2009) 3:18 %I BioMed Central %G en_US %U http://hdl.handle.net/1963/3630 %1 674 %2 Physics %3 Statistical and Biological Physics %$ Submitted by Andrea Wehrenfennig (andreaw@sissa.it) on 2009-05-07T10:19:22Z\\nNo. of bitstreams: 1\\n1752-0509-3-18.pdf: 1143957 bytes, checksum: 3f6f6d33e3da5ee922c0a2c47af61560 (MD5) %R 10.1186/1752-0509-3-18